- #Antibody sequence analysis trial#
- #Antibody sequence analysis license#
- #Antibody sequence analysis series#
Vaccination strategies that can induce more potent, more durable, and broader immune responses are important to enhance protection. 11-13 Nonetheless, the vaccine effectiveness against omicron is lower than that against other variants, 14-17 and second booster doses of omicron-containing vaccines have been authorized in the United States. 8-10īooster immunization with 50-μg mRNA-1273 improves neutralizing antibody responses against variants and vaccine effectiveness against Covid-19. 3-7 Omicron variants continue to cause substantial numbers of illnesses and deaths. In 2022, omicron (B.1.1.529 ) and omicron subvariants (BA.2, BA.2.12.1, BA.4, and BA.5), the most antigenically divergent variants to date, outcompeted other variants in the context of substantial preexisting population immunity from vaccination, infection, or both. 1,2Įarly in the SARS-CoV-2 pandemic, variants such as beta (B.1.351) and delta (B.1.617.2) emerged that conferred immunologic escape or enhanced transmissibility.
#Antibody sequence analysis series#
In the Coronavirus Efficacy (COVE) trial, the mRNA-1273 vaccine (Moderna) had an acceptable safety profile and 93.2% efficacy against Covid-19 at a median of 5.3 months after the two-dose 100-μg primary series immunization. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are safe and effective against coronavirus disease 2019 (Covid-19). (Funded by Moderna number, NCT04927065.) Introduction The bivalent omicron-containing vaccine mRNA-1273.214 elicited neutralizing antibody responses against omicron that were superior to those with mRNA-1273, without evident safety concerns. Vaccine effectiveness was not assessed in this study in an exploratory analysis, SARS-CoV-2 infection occurred in 11 participants after the mRNA-1273.214 booster and in 9 participants after the mRNA-1273 booster. Safety and reactogenicity were similar with the two booster vaccines. In addition, 50-μg mRNA-1273.214 and 50-μg mRNA-1273 elicited geometric mean titers of 727.4 (95% CI, 632.8 to 836.1) and 492.1 (95% CI, 431.1 to 561.9), respectively, against omicron BA.4 and BA.5 (BA.4/5), and the mRNA-1273.214 booster also elicited higher binding antibody responses against multiple other variants (alpha, beta, gamma, and delta) than the mRNA-1273 booster. In participants with no previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the geometric mean titers of neutralizing antibodies against the omicron BA.1 variant were 2372.4 (95% confidence interval, 2070.6 to 2718.2) after receipt of the mRNA-1273.214 booster and 1473.5 (95% CI, 1270.8 to 1708.4) after receipt of the mRNA-1273 booster. The median time between the first and second boosters was similar for mRNA-1273.214 (136 days) and mRNA-1273 (134 days). Sequential groups of participants received 50 μg of mRNA-1273.214 (437 participants) or mRNA-1273 (377 participants) as a second booster dose. The primary objectives were to assess the safety, reactogenicity, and immunogenicity of mRNA-1273.214 at 28 days after the booster dose. We administered mRNA-1273.214 or mRNA-1273 as a second booster in adults who had previously received a two-dose (100-μg) primary series and first booster (50-μg) dose of mRNA-1273 (≥3 months earlier). In this ongoing, phase 2–3 study, we compared the 50-μg bivalent vaccine mRNA-1273.214 (25 μg each of ancestral Wuhan-Hu-1 and omicron B.1.1.529 spike messenger RNAs) with the previously authorized 50-μg mRNA-1273 booster. The safety and immunogenicity of the bivalent omicron-containing mRNA-1273.214 booster vaccine are not known. The most trusted, influential source of new medical knowledge and clinical best practices in the world.
#Antibody sequence analysis license#
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#Antibody sequence analysis trial#
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